Gut microbiota in COVID-19: key microbial changes, potential mechanisms and clinical applications

  • Tregoning, JS, Flight, KE, Higham, SL, Wang, Z. & Pierce, BF Advancing the COVID-19 vaccine effort: viruses, vaccines, and variants versus efficacy, effectiveness, and escape. born Rev. Immunol. 21626–636 (2021).

    CAS PubMed PubMed Central Google Scholar

  • Files, JK et al. Post-COVID-19 symptom duration is associated with SARS-CoV-2-specific immune responses. JCI Insight 6e151544 (2021).

    PubMed Central Google Scholar

  • Lamers, MM et al. SARS-CoV-2 productively infects human intestinal enterocytes. science 36950–54 (2020).

    CAS PubMed Google Scholar

  • Zhang, R. et al. TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes. science Immunol. 5eabc3582 (2020).

    CAS PubMed PubMed Central Google Scholar

  • Zuo, T. et al. Representing fecal SARS-CoV-2 viral activity in association with gut microbiota composition in patients with COVID-19. intestine 70276–284 (2020).

    PubMed Google Scholar

  • Xiao, F. et al. Infectious SARS-CoV-2 in feces of patients with severe COVID-19. emerge infect Dis. 261920 (2020).

    CAS PubMed PubMed Central Google Scholar

  • Natarajan, A. et al. Gastrointestinal symptoms and fecal shedding of SARS-CoV-2 RNA suggest prolonged gastrointestinal infection. with 3371–387 (2022).

    CAS PubMed Google Scholar

  • Zollner, A. et al. Post-acute COVID-19 is characterized by persistence of intestinal viral antigen in inflammatory bowel disease. Gastroenterology 163495–506 (2022).

    CAS PubMed Google Scholar

  • Cheung, KS et al. Gastrointestinal manifestations of SARS-CoV-2 infection and virus load in faecal samples from a Hong Kong cohort: systematic review and meta-analysis. Gastroenterology 15981–95 (2020).

    CAS PubMed Google Scholar

  • Mao, R. et al. Manifestations and prognosis of gastrointestinal and liver involvement in patients with COVID-19: a systematic review and meta-analysis. Lancet Gastroenterol. Hepatol. 5667–678 (2020).

    PubMed PubMed Central Google Scholar

  • Song, Y. et al. SARS-CoV-2-induced diarrhea as an onset symptom in patients with COVID-19. intestine 691143–1144 (2020).

    CAS PubMed Google Scholar

  • Wang, D. et al. Clinical characteristics of 138 patients hospitalized with 2019 coronavirus-infected pneumonia in Wuhan, China. JAMA 3231061–1069 (2020).

    CAS PubMed PubMed Central Google Scholar

  • Gilbert, JA et al. Current knowledge of the human microbiome. night with 24392–400 (2018).

    CAS PubMed PubMed Central Google Scholar

  • Rothschild, D. et al. Environment dominates over host genetics in shaping the human gut microbiota. Nature 555210–215 (2018).

    CAS PubMed Google Scholar

  • Kurilshikov, A. et al. Large-scale association analyzes identify host factors that influence the composition of the human gut microbiome. born rider 53156–165 (2021).

    CAS PubMed PubMed Central Google Scholar

  • Wolter, M. et al. Taking advantage of diet to design the intestinal microbiome. born Reverend Gastroenterol. Hepatol. 18885–902 (2021).

    CAS PubMed Google Scholar

  • Ruff, WE, Greiling, TM and Kriegel, MA Host-microbiota interactions in immune-mediated diseases. born rev. Microbiol. 18521–538 (2020).

    CAS PubMed Google Scholar

  • Groves, HT, Higham, SL, Moffatt, MF, Cox, MJ & Tregoning, JS Respiratory viral infection alters gut microbiota by inducing inappetence. mBio 11e03236-19 (2020).

    CAS PubMed PubMed Central Google Scholar

  • Zhang, D. et al. The cross-talk between gut and lung microbiota in common lung diseases. In front. Microbiol. 11301 (2020).

    CAS PubMed PubMed Central Google Scholar

  • Sun, Z. et al. Gut microbiome alterations and gut barrier dysfunction are associated with host immune homeostasis in patients with COVID-19. BMC Med. 2024 (2022).

    CAS PubMed PubMed Central Google Scholar

  • Vatanen, T. et al. Variation in microbiome LPS immunogenicity contributes to autoimmunity in humans. cell 165842–853 (2016).

    CAS PubMed PubMed Central Google Scholar

  • Anand, S. & Mande, SS Diet, microbiota and the gut-lung connection. In front. Microbiol. 92147 (2018).

    PubMed PubMed Central Google Scholar

  • Parrot, T. et al. MAIT cell activation and dynamics associated with COVID-19 disease severity. science Immunol. 5eabe1670 (2020).

    PubMed PubMed Central Google Scholar

  • Legoux, F., Salou, M. & Lantz, O. MAIT cell development and functions: the microbial connection. immunity 53710–723 (2020).

    CAS PubMed Google Scholar

  • Hashimoto, T. et al. ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature 487477–481 (2012).

    CAS PubMed PubMed Central Google Scholar

  • Viana, SD, Nunes, S. & Reis, F. ACE2 imbalance as a key player for poor outcomes in COVID-19 patients with age-related comorbidities: role of gut microbiota dysbiosis. Aging Nothing. rev. 62101123 (2020).

    CAS PubMed PubMed Central Google Scholar

  • Gaibani, P. et al. The intestinal microbiota of critical patients with COVID-19. In front. cell infect Microbiol. 11670424 (2021).

    CAS PubMed PubMed Central Google Scholar

  • Gu, S. et al. Alterations of the intestinal microbiota in patients with 2019 coronavirus disease or H1N1 influenza. Clin. infect Dis. 712669–2678 (2020).

    CAS PubMed Google Scholar

  • Ren, Z. et al. Alterations in human oral and intestinal microbiomes and lipidomics in COVID-19. intestine 701253–1265 (2021).

    CAS PubMed Google Scholar

  • Xu, R. et al. Temporal association between human upper respiratory microbiomes and gut bacteria during the course of COVID-19 in adults. Commun. Biol. 4240 (2021).

    CAS PubMed PubMed Central Google Scholar

  • Mizutani, T. et al. Correlation analysis between gut microbiota alterations and cytokine response in patients with coronavirus disease during hospitalization. Microbiol. spectrum 10e0168921 (2022).

    PubMed Google Scholar

  • Rafiqul Islam, S. et al. Dysbiosis of oral and gut microbiomes in patients infected with SARS-CoV-2 in Bangladesh: elucidating the role of opportunistic gut microbes. In front. with 9163 (2022).

    Google Scholar

  • Reinold, J. et al. A pro-inflammatory gut microbiome characterizes patients infected with SARS-CoV-2 and reduced connectivity of an anti-inflammatory bacterial network is associated with severe COVID-19. In front. cell infect Microbiol. 111154 (2021).

    Google Scholar

  • Tang, L. et al. Clinical significance of the correlation between changes in major gut bacterial species and severity of COVID-19. engineering 61178–1184 (2020).

    CAS PubMed Google Scholar

  • Tao, W. et al. Analysis of the intestinal microbiota in patients with COVID-19 and its correlation with the inflammatory factor IL-18. Med. Microecol. 5100023 (2020).

    PubMed PubMed Central Google Scholar

  • Wu, Y. et al. Altered oral and intestinal microbiota and their association with SARS-CoV-2 viral load in patients with COVID-19 during hospitalization. NPJ Biofilms Microbiomes 761 (2021).

    CAS PubMed PubMed Central Google Scholar

  • Yes, YK et al. Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19. intestine 70698–706 (2021).

    CAS PubMed Google Scholar

  • Li, S. et al. Microbiome profiling using shotgun metagenomic sequencing identified unique microorganisms in COVID-19 patients with altered gut microbiota. In front. Microbiol. 12712081 (2021).

    PubMed PubMed Central Google Scholar

  • Zuo, T. et al. Alterations in the intestinal microbiota of patients with COVID-19 during hospitalization. Gastroenterology 159944–955.e8 (2020).

    CAS PubMed Google Scholar

  • Bolte, EE, Moorshead, D. & Aagaard, KM Maternal and early childhood exposures and their potential to influence microbiome development. Genome Med. 144 (2022).

    PubMed PubMed Central Google Scholar

  • de Steenhuijsen Piters, WA, Binkowska, J. & Bogaert, D. Early life microbiota and respiratory tract infections. Host cell microbe 28223–232 (2020).

    PubMed Google Scholar

  • Renz, H. and Skevaki, C. Early microbial exposures and allergy risks: opportunities for prevention. born Rev. Immunol. 21177–191 (2021).

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