Structural analysis of monkeypox virus to guide the development of broad-spectrum antiviral agents
In a recent study published on the bioRxiv* preprint server, researchers explored the crystal structure of monkeypox virus (MPX) (MPXV) and the complex of VP39, a 2′-O-RNA methyltransferase (MTase) and sinefungin, a pan- MTase inhibitor. Study: Structure of monkeypox virus 2′-O-ribose methyltransferase VP39 in complex with sinefungin provides basis for inhibitor design. Image credit: Marina …